Document Detail


A new dynamic three-dimensional digital color doppler method for quantification of pulmonary regurgitation: validation study in an animal model.
MedLine Citation:
PMID:  12354447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of the present study was to validate a newly developed three-dimensional (3D) digital color Doppler method for quantifying pulmonary regurgitation (PR), using an animal model of chronic PR. BACKGROUND: Spectral Doppler methods cannot reliably be used to assess pulmonary regurgitation. METHODS: In eight sheep with surgically created PR, 27 different hemodynamic states were studied. Pulmonary and aortic electromagnetic (EM) probes and meters were used to provide reference right ventricular (RV) forward and pulmonary regurgitant stroke volumes. A multiplane transesophageal probe was placed directly on the RV and aimed at the RV outflow tract. Electrocardiogram-gated and rotational 3D scans were performed for acquiring dynamic 3D digital velocity data. After 3D digital Doppler data were transferred to a computer workstation, the RV forward and pulmonary regurgitant flow volumes were obtained by a program that computes the velocity vectors over a spherical surface perpendicular to the direction of scanning. RESULTS: Pulmonary regurgitant volumes and RV forward stroke volumes computed by the 3D method correlated well with those by the EM method (r = 0.95, mean difference = 0.51 +/- 1.89 ml/beat for the pulmonary regurgitant volume; and r = 0.91, mean difference = -0.22 +/- 3.44 ml/beat for the RV stroke volume). As a result of these measurements, the regurgitant fractions derived by the 3D method agreed well with the reference data (r = 0.94, mean difference = 2.06 +/- 6.11%). CONCLUSIONS: The 3D digital color Doppler technique is a promising method for determining pulmonary regurgitant volumes and regurgitant fractions. It should have an important application in clinical settings.
Authors:
Yoshiki Mori; Rosemary A Rusk; Michael Jones; Xiang-Ning Li; Timothy Irvine; Arthur D Zetts; David J Sahn
Related Documents :
8314737 - Studies on percutaneous transvenous mitral commissurotomy using a modified transseptal ...
5420077 - Regional pulmonary function in patients with mitral stenosis in relation to haemodynami...
7247327 - Two dimensional echocardiography in valvular heart disease.
15311867 - Vena contracta width as a simple method of assessing mitral valve regurgitation. compar...
1835737 - A ten-year experience with one hundred fifty failing or threatened vein and polytetrafl...
11358657 - Optimization of scantiming in abdominal breathhold contrast-enhanced mra: an empirical ...
Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  40     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-30     Completed Date:  2002-10-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1179-85     Citation Subset:  AIM; IM    
Affiliation:
Oregon Health and Science University, Portland, Oregon 97201-3098, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity / physiology
Disease Models, Animal
Echocardiography, Doppler, Color / instrumentation*
Imaging, Three-Dimensional / instrumentation*
Pulmonary Valve Insufficiency / physiopathology,  ultrasonography*
Reproducibility of Results
Severity of Illness Index
Sheep
Signal Processing, Computer-Assisted / instrumentation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor.
Next Document:  Natriuretic peptide receptors and neutral endopeptidase in mediating the renal actions of a new ther...