Document Detail


A new database of mitochondrial DNA hypervariable regions I and II sequences from 162 Japanese individuals.
MedLine Citation:
PMID:  12056523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A database of mitochondrial DNA (mtDNA) hypervariable region 1 (HV1) and region 2 (HV2) sequences of the mtDNA control region was established from 162 unrelated Japanese individuals. The random match probability and the genetic diversity for this database were 0.96% and 0.997, respectively. Length heteroplasmy in the C-stretch regions located around position 16189 in HVI and 310 in HV2 was observed in 37% and 38% of the samples, respectively. A strategy using internal sequencing primers was devised to obtain confirmed sequences in these length heteroplasmic individuals. This database, combined with other mtDNA sequence databases from the Japanese population, will permit the significance of mtDNA match results to be properly reported in mtDNA typing casework in Japan.
Authors:
K Imaizumi; T J Parsons; M Yoshino; M M Holland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of legal medicine     Volume:  116     ISSN:  0937-9827     ISO Abbreviation:  Int. J. Legal Med.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-06-11     Completed Date:  2002-11-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9101456     Medline TA:  Int J Legal Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  68-73     Citation Subset:  IM    
Affiliation:
National Research Institute of Police Science, Kashiwa, Chiba, Japan. imaizumi@nrips.go.jp
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
DNA, Mitochondrial / blood,  genetics*
Databases, Nucleic Acid / statistics & numerical data*
Forensic Medicine
Genetic Variation
Humans
Japan
Chemical
Reg. No./Substance:
0/DNA, Mitochondrial
Comments/Corrections
Erratum In:
Int J Legal Med. 2005 May;119(3):183

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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