Document Detail

A new cytotoxic pregnanone from Calotropis gigantea.
MedLine Citation:
PMID:  19052526     Owner:  NLM     Status:  MEDLINE    
A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines.
Zhu-Nian Wang; Mao-Yuan Wang; Wen-Li Mei; Zhuang Han; Hao-Fu Dai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-04
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  13     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-04     Completed Date:  2009-01-13     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3033-9     Citation Subset:  IM    
Institute of Crops Genetic Resources, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, P. R. China.
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MeSH Terms
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification,  pharmacology
Calotropis / chemistry*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Magnetic Resonance Spectroscopy
Pregnanolone / analogs & derivatives*,  chemistry,  isolation & purification,  pharmacology
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/calotropone; 128-20-1/Pregnanolone
Erratum In:
Molecules. 2009;14(1):412-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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