Document Detail


A new cytotoxic pregnanone from Calotropis gigantea.
MedLine Citation:
PMID:  19052526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines.
Authors:
Zhu-Nian Wang; Mao-Yuan Wang; Wen-Li Mei; Zhuang Han; Hao-Fu Dai
Related Documents :
9392886 - Multidrug-resistance modulators from stephania japonica.
20051626 - Cxcr1 blockade selectively targets human breast cancer stem cells in vitro and in xenog...
15901996 - Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid ...
17040906 - Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxic...
1310806 - Carcinoma of the vulva: epidemiology and pathogenesis.
23674586 - A portrait of a female body: rubens and helena's legs.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-04
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  13     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-04     Completed Date:  2009-01-13     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3033-9     Citation Subset:  IM    
Affiliation:
Institute of Crops Genetic Resources, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, P. R. China. wangzhunian@yahoo.com.cn
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification,  pharmacology
Calotropis / chemistry*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Pregnanolone / analogs & derivatives*,  chemistry,  isolation & purification,  pharmacology
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/calotropone; 128-20-1/Pregnanolone
Comments/Corrections
Erratum In:
Molecules. 2009;14(1):412-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chemical synthesis of proanthocyanidins in vitro and their reactions in aging wines.
Next Document:  Prevalence of self-reported physically active adults--United States, 2007.