Document Detail

A new covalently bound ceramide from human stratum corneum -omega-hydroxyacylphytosphingosine.
MedLine Citation:
PMID:  18489279     Owner:  NLM     Status:  In-Data-Review    
The outermost layer of the skin, the stratum corneum, consists of non-viable keratin-filled cells, or corneocytes, embedded in a matrix of lipids. The boundary of the cells consists of cross-linked proteins with covalently bound lipids on the outer surface. The spaces between cells are filled with a mixture of ceramides, cholesterol and fatty acids. The stratum corneum provides a protective barrier against water loss through the skin and limits the penetration of potentially harmful substances from the environment. Among the covalently bound lipids on the corneocyte surface are omega-hydroxyacylsphingosine and omega-hydroxyacyl-6-hydroxysphingosine. The previously suspected presence of omega-hydroxyacylphytosphingosine is confirmed in this report through its specific isolation and characterization based on chromatographic behaviour and proton magnetic resonance spectral data.
J Hill; D Paslin; P W Wertz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cosmetic science     Volume:  28     ISSN:  1468-2494     ISO Abbreviation:  Int J Cosmet Sci     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2008-05-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007161     Medline TA:  Int J Cosmet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-30     Citation Subset:  -    
Dows Institute, University of Iowa, Iowa City, IA 52242, USA.
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