Document Detail

A new computerized impedance plethysmograph: accuracy in the detection of proximal deep-vein thrombosis in symptomatic outpatients.
MedLine Citation:
PMID:  2048046     Owner:  NLM     Status:  MEDLINE    
Because of the lack of specificity of the clinical diagnosis it is appropriate in patients with clinically suspected deep-vein thrombosis to apply an objective test before starting anticoagulant treatment. Impedance plethysmography is a highly accurate technique for the detection of proximal-vein thrombosis with a reported sensitivity and specificity of 93 and 97%, respectively. In all previous reported evaluations of impedance plethysmography an apparatus which was developed in 1971 was used. A new computerized impedance plethysmography, using a novel device to measure impedance, was blindly compared against venography in 443 consecutive outpatients with clinically suspected deep-vein thrombosis. In the first phase of the study the computerized impedance plethysmography test results of 242 symptomatic patients were used to develop a discriminant line. Subsequently, this discriminant line was validated in the second phase of the study in another 201 symptomatic patients. The combined sensitivity and specificity of these two phases for proximal-vein thrombosis was 91% [95% confidence interval (CI), 86 to 94%] and 94% and (95% CI, 90 to 96%), respectively, which compares favourably with impedance plethysmography. It is concluded that computerized impedance plethysmography is a simple, portable, non-invasive technique with a high accuracy for the detection of proximal vein thrombosis. However, before computerized impedance plethysmography can be used as the only test in the diagnosis of deep-vein thrombosis, the safety of withholding anticoagulant treatment to patients with repeated normal computerized test results should be assessed during long-term follow-up studies.
P Prandoni; A W Lensing; M V Huisman; J J Jonker; M Vigo; J J Borm; H R Büller; A K Sing; M Carta; J W ten Cate
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  65     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-07-17     Completed Date:  1991-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  229-32     Citation Subset:  IM    
Second Institute of Internal Medicine, University Hospital of Padua, Italy.
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MeSH Terms
Aged, 80 and over
Ambulatory Care
Middle Aged
Plethysmography, Impedance / methods*
Prospective Studies
Reproducibility of Results
Thrombophlebitis / diagnosis*
Comment In:
Thromb Haemost. 1992 Jul 6;68(1):89   [PMID:  1514181 ]
Thromb Haemost. 1991 Mar 4;65(3):221-2   [PMID:  2048045 ]

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