Document Detail


A new compound, brefeldin A formylate, from Penicillium sp. strain HLKG-44.
MedLine Citation:
PMID:  19177238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel compound named as brefeldin A formylate (1), together with two known compounds, brefeldin A (2) and ergosterol (3), was isolated from the Penicillium sp. strain HLKG-44, which was isolated from polluted environment in Fujian Province. Their structures were identified based on the spectral and X-ray crystallographic analyses. The compound 1, brefeldin A formylate, exhibited moderate cytotoxic activity against the human lung cancer cell line A549 with IC(50) value of 18.9 microg/ml by the MTT assay protocol.
Authors:
Han-Wen Zhang; Hong-Ming Cheng; Hua Fang; Yu-Fen Zhao; Mei-Juan Fang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Asian natural products research     Volume:  11     ISSN:  1477-2213     ISO Abbreviation:  J Asian Nat Prod Res     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-29     Completed Date:  2009-04-02     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  100888334     Medline TA:  J Asian Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  54-7     Citation Subset:  IM    
Affiliation:
Key Laboratory for Chemical Biology of Fujian Province College of Chemistry and Chemical Engineering, Department of Chemistry, Xiamen University, Xiamen, China.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / chemistry,  isolation & purification*,  pharmacology
Brefeldin A / analogs & derivatives,  chemistry,  isolation & purification
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Ergosterol / chemistry,  isolation & purification
Humans
Molecular Conformation
Molecular Structure
Penicillium / chemistry*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/brefeldin A formylate; 20350-15-6/Brefeldin A; 57-87-4/Ergosterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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