| A new common marker for premalignant and malignant hepatocytes induced in the rat by chemical carcinogens. | |
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MedLine Citation:
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PMID: 163316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new common antigen, preneoplastic (PN), was found in every early and late hyperplastic nodule and in every primary hepatoma induced by N-2-fluorenylacetamide, ethionine, 3-methyl-4-dimethylaminoazobenzene, dimethylnitrosamine, or diethylnitrosamine in three strains of rats (CFN, F344, and BUF). It so far has not been found in normal adult rat liver, liver surrounding nodules or cancer, fetal liver, amniotic fluid, adult rat serum, sera from rats with hyperplastic nodules or primary hepatomas, or various normal rat tissues. Immunofluorescent staining indicated the PN antigen was present in the cytoplasm of hepatocytes in hyperplastic nodules and in primary hepatomas. |
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Authors:
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K Okita; L H Kligman; E Farber |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 54 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-05-10 Completed Date: 1975-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 199-202 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Neoplasm* Carcinogens* Carcinoma, Hepatocellular / chemically induced, immunology* Cytoplasm / immunology Ethionine Fluorenes Fluorescent Antibody Technique Liver / immunology* Liver Neoplasms / chemically induced, immunology* Neoplasms, Experimental / chemically induced, immunology Nitrosamines Precancerous Conditions / immunology* Rats Rats, Inbred BUF Rats, Inbred F344 p-Dimethylaminoazobenzene |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Carcinogens; 0/Fluorenes; 0/Nitrosamines; 13073-35-3/Ethionine; 60-11-7/p-Dimethylaminoazobenzene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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