Document Detail

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.
MedLine Citation:
PMID:  23322269     Owner:  NLM     Status:  MEDLINE    
This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
Qingzhi Zhang; Agnieszka Kulczynska; David J Webb; Ian L Megson; Nigel P Botting
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  49     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-22     Completed Date:  2013-06-26     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1389-91     Citation Subset:  IM    
University of St Andrews, EaStChem School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife KY16 9ST, UK.
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MeSH Terms
Acute Kidney Injury / drug therapy
Guanidines / chemistry
Nitric Oxide / metabolism*
Prodrugs / chemistry,  metabolism*,  therapeutic use
Vasodilator Agents / chemistry,  metabolism*,  therapeutic use
gamma-Glutamyltransferase / metabolism*
Grant Support
063729//Wellcome Trust; 063729/Z/01/Z//Wellcome Trust
Reg. No./Substance:
0/Guanidines; 0/Prodrugs; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 13115-21-4/hydroxyguanidine; EC

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