Document Detail


A new chromosome type replacing the double minutes in a mouse tumor.
MedLine Citation:
PMID:  77207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For several years the SEWA mouse ascites tumor has been a carrier of double minute chromosomes (DMs), some 90% of its cells containing from one to several hundred DMs. In one specific subline of this tumor, the cells with DMs had decreased in frequency to less than 5% of the cells. At the same time, the stemline chromosome number had increased from 43 to around 50. This was due to the presence, in addition to the ordinary telocentric chromosomes, of a varying number of medium-sized metacentrics. The fact that these chromosomes deviated from ordinary mouse chromosomes in special features, such as median centromeric position, early DNA replication, and complete lack of centromeric heterochromatin, indicates that they represent a new type of chromosome. Their striking agreement with the DMs in many properties makes it tempting to associate their origin with the disappearance of the DMs.
Authors:
A Levan; G Levan; N Mandahl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  20     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1978  
Date Detail:
Created Date:  1978-07-24     Completed Date:  1978-07-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  12-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography
Carcinoma, Ehrlich Tumor / genetics*
Cell Line
Cells, Cultured
Chromosomes / ultrastructure*
DNA Replication
Hematopoietic Stem Cells / ultrastructure
Heterochromatin / ultrastructure
Mice
Staining and Labeling
Chemical
Reg. No./Substance:
0/Heterochromatin

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