Document Detail


A new chromosomal three-way rearrangement involving MLL masked by a t(9;19)(p11;p13) in an infant with acute myeloid leukemia.
MedLine Citation:
PMID:  19167614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infants diagnosed with acute myelogenous leukemia (AML) are likely to have subtypes M4 or M5 characterized by 11q23 abnormalities like a t(9;11)(p22;q23). Detection of all possible types of chromosomal abnormalities, including mixed lineage leukemia (MLL) gene rearrangements at 11q23, is of importance for the identification of biological subgroups, which might differ in drug resistance and/or clinical outcome. Here, we report the clinical, conventional banding and molecular cytogenetics data of a 6-month-old boy with an AML-M5 presenting with a unique cryptic rearrangement involving the MLL gene: a three-way t(9;19;11)(p11.2;p13.1;q23).
Authors:
Terezinha de Jesus Marques-Salles; Thomas Liehr; Hasmik Mkrtchyan; Susana C Raimondi; Mariana Tavares de Souza; Amanda Faria de Figueiredo; Soraia Rouxinol; Fernanda C Jordy Macedo; Eliana Abdelhay; Neide Santos; Maria Luiza Macedo Silva
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  189     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM    
Affiliation:
Genetic Department of University Federal of Pernambuco, Av. Prof. Moraes Rego, 1235-Cidade Universitária, Recife-PE-CEP: 50670-901 Brasil. tjmsalles@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human, Pair 11 / genetics*
Chromosomes, Human, Pair 19 / genetics*
Chromosomes, Human, Pair 9 / genetics*
Humans
In Situ Hybridization, Fluorescence
Infant
Karyotyping
Leukemia, Myeloid, Acute / genetics*
Male
Myeloid-Lymphoid Leukemia Protein / genetics*
Translocation, Genetic / genetics*
Chemical
Reg. No./Substance:
149025-06-9/Myeloid-Lymphoid Leukemia Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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