| A new cause of haemolytic anaemia in the newborn. A description of an unstable fetal haemoglobin: F Poole, alpha2-G-gamma2 130 trptophan yeilds glycine. | |
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MedLine Citation:
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PMID: 1127124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a newborn twin with haemolytic anaemia an unstable fetal haemoglobin was found to be the cause. The anaemia improved spontaneously with the disappearance of the fetal haemoglobin. The new Hb F (alpha2gamma2) variant was shown to have a glycine at position 130 of the 146 residues of the gamma chain. This portion is inside the globin molecule and in all known normal globins it is occupied by a residue with a bulky hydrophobic side chain. Its replacement by glycine which has no side chain would be expected to cause instability. The human gamma-chains may either have a glycine or an alanine at position 136. Evidence is brought forward to suggest that in the abnormal chain position 136 is occupied by glycine. |
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Authors:
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J P Lee-Potter; R A Deacon-Smith; M J Simpkiss; H Kamuzora; H Lehmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pathology Volume: 28 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 1975 Apr |
Date Detail:
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Created Date: 1975-08-07 Completed Date: 1975-08-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 317-20 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Anemia, Hemolytic / etiology* Diseases in Twins Fetal Hemoglobin* / analysis Glycine / analysis Hemoglobins, Abnormal* Humans Infant, Newborn Infant, Newborn, Diseases / etiology* Male Tryptophan / analysis |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins, Abnormal; 56-40-6/Glycine; 73-22-3/Tryptophan; 9034-63-3/Fetal Hemoglobin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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