Document Detail


A new cause of haemolytic anaemia in the newborn. A description of an unstable fetal haemoglobin: F Poole, alpha2-G-gamma2 130 trptophan yeilds glycine.
MedLine Citation:
PMID:  1127124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a newborn twin with haemolytic anaemia an unstable fetal haemoglobin was found to be the cause. The anaemia improved spontaneously with the disappearance of the fetal haemoglobin. The new Hb F (alpha2gamma2) variant was shown to have a glycine at position 130 of the 146 residues of the gamma chain. This portion is inside the globin molecule and in all known normal globins it is occupied by a residue with a bulky hydrophobic side chain. Its replacement by glycine which has no side chain would be expected to cause instability. The human gamma-chains may either have a glycine or an alanine at position 136. Evidence is brought forward to suggest that in the abnormal chain position 136 is occupied by glycine.
Authors:
J P Lee-Potter; R A Deacon-Smith; M J Simpkiss; H Kamuzora; H Lehmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  28     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-08-07     Completed Date:  1975-08-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  317-20     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Anemia, Hemolytic / etiology*
Diseases in Twins
Fetal Hemoglobin* / analysis
Glycine / analysis
Hemoglobins, Abnormal*
Humans
Infant, Newborn
Infant, Newborn, Diseases / etiology*
Male
Tryptophan / analysis
Chemical
Reg. No./Substance:
0/Hemoglobins, Abnormal; 56-40-6/Glycine; 73-22-3/Tryptophan; 9034-63-3/Fetal Hemoglobin
Comments/Corrections

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