Document Detail

A new cardiac MASTer switch for the renin-angiotensin system.
MedLine Citation:
PMID:  16585956     Owner:  NLM     Status:  MEDLINE    
The aspartyl protease renin was first isolated from the kidney by Tigerstedt more than a century ago. In the kidney, renin secretion is tightly linked to sodium intake and renal perfusion pressure, reflecting the important role of the renin-angiotensin system (RAS) in controlling body fluid volume and blood pressure. The study by Mackins et al. in this issue of the JCI describes a novel source of renin: the mast cell (see the related article beginning on page 1063). This discovery suggests a distinct pathway for activation of the RAS that may have a particular impact on the pathogenesis of chronic tissue injury as well as more acute pathology such as arrhythmias in the heart.
Thu H Le; Thomas M Coffman
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  116     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-04     Completed Date:  2006-05-16     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  866-9     Citation Subset:  AIM; IM    
Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA.
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MeSH Terms
Blood Pressure
Cardiovascular Diseases / etiology
Mast Cells / metabolism*
Myocardium / cytology
Renin / metabolism*
Renin-Angiotensin System / physiology*
Reg. No./Substance:
Comment On:
J Clin Invest. 2006 Apr;116(4):1063-70   [PMID:  16585966 ]

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