| A new canine model for evaluating blood prosthetic arterial graft interactions. | |
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MedLine Citation:
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PMID: 1833406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various models have been proposed to examine blood-prosthetic materials interactions in terms of the effect of the prosthetic material on platelet structure and function, blood coagulation and fibrinolysis, and tissue infiltrates (cellular or acellular). In addition, these models have been used to examine the change in the graft surface over time. Particular difficulties in examining graft-materials interactions include species differences, short residence time for blood-materials interactions with commonly employed short grafts, and length of study limitations with ex vivo shunts. In this paper we report a canine, carotid-aorta subcutaneous prosthetic graft model. The specific advantages of this model are the length of the graft, which allows prolonged contact of blood with the prosthetic surface; the subcutaneous location of the graft, which allows repeated sampling of blood along the graft; and the healing characteristics of canine grafts. We selected the canine model because the healing characteristics are morphologically similar to those in humans in that endothelialization of the prosthetic surface is limited. Other models, such as the pig, are favored for use when examining blood coagulation, platelet, or fibrinolytic studies; however, these models can fully endothelialize prosthetic surfaces. |
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Authors:
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C M Brophy; R K Ito; W C Quist; M S Rosenblatt; M Contreras; A Tsoukas; F W LoGerfo |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of biomedical materials research Volume: 25 ISSN: 0021-9304 ISO Abbreviation: J. Biomed. Mater. Res. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-11-08 Completed Date: 1991-11-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0112726 Medline TA: J Biomed Mater Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1031-8 Citation Subset: IM |
Affiliation:
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New England Deaconess Hospital, Harvard Surgical Service, Boston, Massachusetts 02215. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials* Blood Coagulation Blood Vessel Prosthesis* Dogs Fibrinolysis Hemostasis Humans Microscopy, Electron, Scanning Platelet Aggregation Polyethylene Terephthalates |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL21796/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Polyethylene Terephthalates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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