Document Detail


A new bronchodilating agent, procaterol, in preventing exercise-induced asthma.
MedLine Citation:
PMID:  2946644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to verify the effectiveness of procaterol, a recent and specific beta-2-adrenoceptor stimulant, in preventing exercise-induced asthma (EIA). Twelve asthmatic patients were selected aged 18.6 +/- 5.6 years with a positive response to EIA and a basal forced expiratory volume of the first second (FEV1) better than 80% of predicted. The patients underwent four bronchoprovocation challenges on four consecutive days. On the first day they performed an inclusion test, and, on the three subsequent days, they were submitted, to three identical standardized challenges according to a randomized design. Fifteen minutes before, procaterol (20 mcg), salbutamol (200 mcg) and a placebo were administered as metered aerosol. No pharmacological treatment was given for 24 h (48 h for antihistamines) before each challenge. The test was carried out running on treadmill (10% grade) for 7 min. Room temperature (20-25 degrees C) and relative humidity (40-55%) were maintained constant. At baseline, 15 min before, 5, 10, 15, 30 and 60 min after the exercise, lung function was assessed. Basal mean values of FEV1 were 94.7, 94.9, 90.7 and 91.5% of predicted for the inclusion and the three protected tests, respectively, without significant differences. The FEV1 mean values showed a mild bronchodilation 15 min after salbutamol (+13.2%, p less than 0.006) and procaterol (+8%, NS). At every considered time all indices showed a significant gap (p less than 0.01) between drugs and the placebo with no appreciable differences between procaterol and salbutamol.
Authors:
F Ioli; C F Donner; C Fracchia; G Manini; A Patessio; E L Spada; C Vecchio
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of clinical pharmacology research     Volume:  6     ISSN:  0251-1649     ISO Abbreviation:  Int J Clin Pharmacol Res     Publication Date:  1986  
Date Detail:
Created Date:  1987-01-06     Completed Date:  1987-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8110183     Medline TA:  Int J Clin Pharmacol Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  389-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Albuterol / therapeutic use
Asthma / prevention & control*
Asthma, Exercise-Induced / prevention & control*
Bronchodilator Agents / therapeutic use*
Child
Ethanolamines / therapeutic use*
Female
Forced Expiratory Volume
Humans
Male
Procaterol
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 0/Ethanolamines; 18559-94-9/Albuterol; 72332-33-3/Procaterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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