Document Detail


A new brain area affected by 3,4-methylenedioxymethamphetamine: A microdialysis-biotelemetry study.
MedLine Citation:
PMID:  18727928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The widespread abuse of 3,4-methylenedioxymethamphetamine (MDMA) has intensified the need to learn more about this drug (e.g. its effects, its mechanism of action, brain areas affected). MDMA-induced hyperthermia is a severe physiological event not only because it can produce severe adverse consequences in human as well as experimental animals, but also because it plays a major role in determining the severity of the long-term MDMA-induced neurotoxicity that occurs. However, the effects of MDMA on the preoptic anterior hypothalamus, the main brain area responsible for control of body temperature, are still unknown. In vivo microdialysis-biotelemetry and pharmacological testing were used to determine whether the preoptic anterior hypothalamus is among the brain areas affected by MDMA by investigating the role of the dopamine neurotransmitter system. We examined the effect of a hyperthermic dose of MDMA on the extracellular level of dopamine in the preoptic anterior hypothalamus, and whether this effect is related to the acute hyperthermic response. The administration of a hyperthermic dose of MDMA (20 mg/kg) is accompanied by an increase in the extracellular level of dopamine in the preoptic anterior hypothalamus. Both the hyperthermia and augmented level of dopamine in the preoptic anterior hypothalamus after intraperitoneal injection of MDMA were significantly reduced by the pretreatment with D(1)-selective dopamine receptor antagonist, R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzapine (SCH 23390). These data provide the first in vivo evidence that the effects of MDMA extend to preoptic anterior hypothalamus.
Authors:
Khalid Benamar; Ellen B Geller; Martin W Adler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-08-13
Journal Detail:
Title:  European journal of pharmacology     Volume:  596     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  84-8     Citation Subset:  IM    
Affiliation:
Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA. kbenamar@temple.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature / drug effects
Brain / anatomy & histology,  drug effects*,  metabolism
Central Nervous System Agents / pharmacology*
Dopamine / metabolism
Extracellular Space / metabolism
Male
Microdialysis
N-Methyl-3,4-methylenedioxyamphetamine / pharmacology*
Preoptic Area / drug effects,  metabolism
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1 / antagonists & inhibitors
Telemetry
Grant Support
ID/Acronym/Agency:
DA 06650/DA/NIDA NIH HHS; DA 13429/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Agents; 0/Receptors, Dopamine D1; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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