Document Detail


A new boronic acid-based fluorescent sensor for L-dihydroxyphenylalanine.
MedLine Citation:
PMID:  23229143     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Catecholamines, such as dopamine and L-dihydroxyphenylalanine (L-DOPA), are associated with different physiological functions and diseases. In our recent studies, a novel water-soluble boronic acid compound 3c was identified as a selective fluorescent sensor for L-DOPA. This compound not only has the ability to interact with dopamine and catechol, but also has no fluorescence intensity change for L-DOPA precursors in vivo, such as L-tyrosine.
Authors:
Z Y Wu; X Y Yang; W F Xu; B H Wang; H Fang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug discoveries & therapeutics     Volume:  6     ISSN:  1881-7831     ISO Abbreviation:  Drug Discov Ther     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-12-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101493809     Medline TA:  Drug Discov Ther     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  238-41     Citation Subset:  IM    
Affiliation:
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University, Ji'nan, China.
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