Document Detail

A new blood pressure measuring apparatus equipped with a microcomputer system for conscious rats.
MedLine Citation:
PMID:  3613605     Owner:  NLM     Status:  MEDLINE    
In order to measure the systolic blood pressure of conscious rats without thermal stress, a highly sensitive pulse sensor was developed using a light-emitting diode-photo diode system. The combination of this pulse sensor and microcomputer system led to the development of a six-channel automatic blood pressure measuring apparatus for rats. It can measure the systolic tail arterial pressure of conscious rats at 28-30 degrees C. The relationship between direct carotid arterial pressure (Y) and indirect tail arterial pressure (X) in conscious spontaneously hypertensive rats can be expressed as follows: Y = 0.95X + 19.9 (mm Hg, r = 0.988, 28 degrees C). The new apparatus was also used to confirm the acute hypotensive effects of hydralazine, nifedipine, and pindolol in spontaneously hypertensive rats and the subacute antihypertensive effect of trichlormethiazide in desoxycorticosterone/saline hypertensive rats.
S Matsuda; K Kurokawa; K Higuchi; N Imamura; H Hakata; M Ueda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacological methods     Volume:  17     ISSN:  0160-5402     ISO Abbreviation:  J Pharmacol Methods     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-09-02     Completed Date:  1987-09-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7806596     Medline TA:  J Pharmacol Methods     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  361-76     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / pharmacology
Blood Pressure Determination / instrumentation*
Heart Rate / drug effects
Rats, Inbred Strains
Regional Blood Flow
Tail / blood supply
Reg. No./Substance:
0/Antihypertensive Agents

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