Document Detail


A new biodegradable braided self-expandable PLGA prostatic stent: an experimental study in the rabbit.
MedLine Citation:
PMID:  18643724     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The biodegradable PLGA (a copolymer of L-lactide and glycolide) urethral stent with a spiral configuration has been used clinically for the prevention of postoperative urinary retention after different types of thermal therapy for benign prostatic hyperplasia. A new braiding pattern for this stent has recently been developed by our group. The aim here was to investigate the in situ degradation and biocompatibility of the new braided stent in the rabbit urethra. MATERIALS AND METHODS: PLGA stents with a one-over-one braiding pattern and steel stents served as controls that were inserted into the posterior urethras of 24 male rabbits using a special delivery instrument. The animals were sacrificed after 1 week, 1 month, 2 months, or 4 months, and light microscopy and histologic analyses were performed. RESULTS: The delivery instrument worked well and cystoscopy was not needed in the insertion process. The braided PLGA stents degraded smoothly in 1 to 2 months. The metallic stents induced more epithelial hyperplasia and epithelial changes than the biodegradable stents at all time points analyzed. These differences increased during follow-up. CONCLUSION: The degradation process was well controlled and the biodegradable stents were more biocompatible than the metallic stents. The new stent can be inserted into the posterior urethra without cystoscopic aid.
Authors:
Andres Kotsar; Taina Isotalo; Joonas Mikkonen; Hanne Juuti; Paula M Martikainen; Martti Talja; Minna Kellomäki; Pertti Törmälä; Teuvo L J Tammela
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of endourology / Endourological Society     Volume:  22     ISSN:  0892-7790     ISO Abbreviation:  J. Endourol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-07-22     Completed Date:  2008-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807503     Medline TA:  J Endourol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1065-9     Citation Subset:  IM    
Affiliation:
Department of Urology, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland. andres.kotsar@pshp.fi
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MeSH Terms
Descriptor/Qualifier:
Absorbable Implants*
Animals
Biocompatible Materials
Epithelium / pathology
Lactic Acid
Male
Materials Testing*
Models, Animal
Polyglycolic Acid
Prostate / surgery
Prosthesis Design
Rabbits
Stents*
Urethra / pathology*,  surgery*
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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