Document Detail


A new approach to the treatment of acute schistosomiasis.
MedLine Citation:
PMID:  2517865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical and experimental evidence indicates that steroids act synergistically with schistosomicides in the treatment of Katayama syndrome. Due to the low efficacy of schistosomicides in the acute toxaemic phase of schistosomiasis, some authors have suggested that specific treatment for schistosomiasis should be delayed, in these patients, until the disease has entered it's chronic stage (Stuiver, 1984; Harries and Cook, 1987). A dramatic improvement (quick amelioration of symptoms and higher cure rates) was observed when patients with acute schistosomiasis were treated with steroids and schistosomicides. We do not know the explanation for the synergistic effect between steroids and schistosomicides but it has been demonstrated that the association of drugs affected, in some way, the fecundity of S. mansoni worms. The data and arguments presented here reinforce the need to use steroids in conjunction with schistosomicides for the treatment of patients with Katayama syndrome. This approach will give better cure rates, speed the recovery time (reducing the demand for hospital treatment) and improve the quality of medical care.
Authors:
J R Lambertucci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Memórias do Instituto Oswaldo Cruz     Volume:  84 Suppl 1     ISSN:  0074-0276     ISO Abbreviation:  Mem. Inst. Oswaldo Cruz     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-08-08     Completed Date:  1990-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7502619     Medline TA:  Mem Inst Oswaldo Cruz     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, Federal University of Minas Gerais, Department of Internal Medicine, Belo Horizonte (MG), Brazil.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Animals
Child
Child, Preschool
Dexamethasone / therapeutic use*
Drug Synergism
Drug Therapy, Combination
Humans
Mice
Mice, Inbred CBA
Nitroquinolines / therapeutic use*
Oxamniquine / therapeutic use*
Praziquantel / therapeutic use*
Prednisone / therapeutic use*
Schistosomiasis mansoni / drug therapy*
Chemical
Reg. No./Substance:
0/Nitroquinolines; 21738-42-1/Oxamniquine; 50-02-2/Dexamethasone; 53-03-2/Prednisone; 55268-74-1/Praziquantel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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