Document Detail


A new approach to the rationale discovery of polymeric biomaterials.
MedLine Citation:
PMID:  17644176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper attempts to illustrate both the need for new approaches to biomaterials discovery as well as the significant promise inherent in the use of combinatorial and computational design strategies. The key observation of this Leading Opinion Paper is that the biomaterials community has been slow to embrace advanced biomaterials discovery tools such as combinatorial methods, high-throughput experimentation, and computational modeling in spite of the significant promise shown by these discovery tools in materials science, medicinal chemistry and the pharmaceutical industry. It seems that the complexity of living cells and their interactions with biomaterials has been a conceptual as well as a practical barrier to the use of advanced discovery tools in biomaterials science. However, with the continued increase in computer power, the goal of predicting the biological response of cells in contact with biomaterials surfaces is within reach. Once combinatorial synthesis, high-throughput experimentation, and computational modeling are integrated into the biomaterials discovery process, a significant acceleration is possible in the pace of development of improved medical implants, tissue regeneration scaffolds, and gene/drug delivery systems.
Authors:
Joachim Kohn; William J Welsh; Doyle Knight
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-07-20
Journal Detail:
Title:  Biomaterials     Volume:  28     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-13     Completed Date:  2007-10-19     Revised Date:  2013-12-06    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  4171-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biocompatible Materials / chemistry*
Combinatorial Chemistry Techniques / methods*,  trends
Computer Simulation
Models, Chemical*
Research / trends
Research Design*
Grant Support
ID/Acronym/Agency:
EB001046/EB/NIBIB NIH HHS; P41 EB001046/EB/NIBIB NIH HHS; P41 EB001046-04/EB/NIBIB NIH HHS; R01 HL060416/HL/NHLBI NIH HHS; R01 HL060416-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials
Comments/Corrections

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