| A new approach to quantifying lung damage after stereotactic body radiation therapy. | |
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MedLine Citation:
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PMID: 21174519 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Radiological pneumonitis and fibrosis are common after stereotactic body radiotherapy (SBRT) but current scoring systems are qualitative and subjective. We evaluated the use of CT density measurements and a deformable registration tool to quantitatively measure lung changes post-SBRT. Material and methods. Four-dimensional CT datasets from 25 patients were imported into an image analysis program. Deformable registration was done using a B-spline algorithm (VelocityAI) and evaluated by landmark matching. The effects of respiration, contrast, and CT scanner on density measurements were evaluated. The relationship between density and clinician-scored radiological pneumonitis was assessed. Results. Deformable registration resulted in more accurate image matching than rigid registration. CT lung density was maximal at end-expiration, and most deformation with breathing occurred in the lower thorax. Use of contrast increased mean lung density by 18 HU (range 16-20 HU; p = 0.004). Diagnostic scans had a lower mean lung density than planning scans (mean difference 57 HU in lung contralateral to tumor; p = 0.048). Post-treatment CT density measurements correlated strongly with clinician-scored radiological pneumonitis (r = 0.75; p < 0.001). Conclusions. Quantitative analysis of changes in lung density correlated strongly with physician-assigned radiologic pneumonitis scores. Deformable registration and CT density measurements permit objective assessment of treatment toxicity. |
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Authors:
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David A Palma; John R van Sörnsen de Koste; Wilko F A R Verbakel; Suresh Senan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-21 |
Journal Detail:
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Title: Acta oncologica (Stockholm, Sweden) Volume: - ISSN: 1651-226X ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709065 Medline TA: Acta Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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