Document Detail


A new approach to practical acute toxicity testing.
MedLine Citation:
PMID:  6667118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD50, is described. Using this, it is possible to obtain with 13 experimental animals adequate information on the acute toxicity and on the LD50. This method has no limitations and applies to drugs, agricultural and industrial chemicals. It can be used for every route of administration.
Authors:
D Lorke
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of toxicology     Volume:  54     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-03-08     Completed Date:  1984-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  275-87     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Lethal Dose 50
Male
Mortality
Rats
Research Design*
Time Factors
Toxicology / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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