Document Detail


A new approach for PEGylation of dendrimers.
MedLine Citation:
PMID:  20558063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dendrimers have emerged as one of the most interesting themes for researchers as a result of unique functional architecture and macromolecular characteristics. The reported methods of PEGylation are very time consuming and required multisteps for synthesis. In present work we have synthesized PEGylated polyamidoamine (PAMAM) dendrimers using epichlorohydrin as a linker. The PEGylated dendrimers were evaluated for color reaction UV, IR and NMR studies and compared with standard data.
Authors:
Hemant Khambete; Surya P Gautam; C Karthikeyan; Suman Ramteke; N S Hari Narayana Moorthy; Piyush Trivedi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-25
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  20     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  4279-81     Citation Subset:  IM    
Copyright Information:
2010. Published by Elsevier Ltd.
Affiliation:
School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal (MP) 462 036, India.
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MeSH Terms
Descriptor/Qualifier:
Dendrimers*
Polyethylene Glycols / chemistry*
Spectrum Analysis / methods
Chemical
Reg. No./Substance:
0/Dendrimers; 0/Polyethylene Glycols

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