Document Detail


A new antioxidative vitamin B6 analogue modulates pathophysiological cell proliferation and damage.
MedLine Citation:
PMID:  10218829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The new large scale synthesis of the yellow colored vitamin B6 analogue 5'-O-phosphono-pyridoxylidenerhodanine (2) (B6PR) leads to oligohydrates of its monosodium salt (4). The light-red hemiheptadecahydrate (8 1/2 hydrate) (4a) was crystallized and its three-dimensional structure determined by X-ray crystallography. Special nucleotide and protein interaction properties together with scavenging antioxidative function are combined in this simple water-soluble vitamin B6 analogues B6PR. High (mM) concentrations were untoxic to 'healthy' not affected cells and primary tissues. Complexation of ions (e.g. Ca2+, Fe2+, and Zn2+), modulation of nitric oxide synthases (NOS I-III), nitric oxide (NO) metabolism, and reactive oxygen species (ROS) was found. Special cytoprotecting, immunomodulating, stimulating and inhibiting activities were observed in vitro, not in comparison with some natural and synthetic pyridoxines. Low B6PR suppressed proliferation, high induced selective cell death of some cancer cell lines. Low B6PR protected HIV-1-infected CD4+ HUT 78 cells against HIV-1-mediated destruction (complete inhibition of HIV-1-induced syncytia formation and cell death) and reduced p24 level. Autoreactive S100beta-specific T cells of Lewis rat, a model of multiple sclerosis, could be influenced. Oxidative damage and age, acquired and inherited disease related pathophysiological disorders can be treated by this new cytopathology-selective versatile acting B6PR.
Authors:
A J Kesel; I Sonnenbichler; K Polborn; L Gürtler; W E Klinkert; M Modolell; A K Nüssler; W Oberthür
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  7     ISSN:  0968-0896     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-07-19     Completed Date:  1999-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  359-67     Citation Subset:  IM; X    
Affiliation:
Max-Planck-Institut für Biochemie, Martinsried, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow Cells / drug effects
CD4-Positive T-Lymphocytes / drug effects
Cell Division / drug effects*
Crystallography, X-Ray
Dose-Response Relationship, Drug
HIV-1 / metabolism
Humans
Mice
Models, Biological
Models, Chemical
Models, Molecular
Nitrites / metabolism
Pyridoxine / analogs & derivatives*,  chemistry*
Rats
Time Factors
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Nitrites; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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