| A new antifungal and antiprotozoal depside from the Andean lichen Protousnea poeppigii. | |
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MedLine Citation:
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PMID: 18058986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracts from the Andean lichens Protousnea poeppigii and Usnea florida displayed antimicrobial activity against the pathogenic fungi Microsporum gypseum, Trichophyton mentagrophytes and T. rubrum with MIC values between 50 and 100 microg/mL. From the active extracts, four main metabolites were isolated and identified as the new depside, isodivaricatic acid, and the known metabolites 5-propylresorcinol, divaricatinic acid and usnic acid. Isodivaricatic acid and divaricatinic acid presented antifungal effect towards M. gypseum with a MIC of 50 microg/mL and against T. mentagrophytes and T. rubrum and with MIC values of 50 and 100 microg/mL, respectively. The new isodivaricatic acid was active towards Leishmania amazonensis, Leishmania brasiliensis and Leishmania infantum promastigotes with 100% lysis at 100 microg/mL.The activity of the new compound decreased on acetylation of the hydroxy groups as well as on methylation of the acid function. The structures were elucidated by spectroscopic means. The spectroscopic data of isodivaricatic acid are presented here for the first time. |
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Authors:
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Guillermo Schmeda-Hirschmann; Alejandro Tapia; Beatriz Lima; Mariano Pertino; Maximiliano Sortino; Susana Zacchino; Antonieta Rojas de Arias; Gabriela Egly Feresin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 22 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-05 Completed Date: 2008-12-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 349-55 Citation Subset: IM |
Affiliation:
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Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile. schmeda@utalca.cl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Infective Agents / chemistry, isolation & purification, pharmacology* Ascomycota / chemistry Bacteria / drug effects* Depsides / chemistry, pharmacology* Drug Evaluation, Preclinical / methods Leishmania / drug effects* Lichens / chemistry* Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Mitosporic Fungi / drug effects* Salicylates / pharmacology Usnea / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Depsides; 0/Salicylates; 0/isodivaricatic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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