Document Detail

A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics.
MedLine Citation:
PMID:  1917695     Owner:  NLM     Status:  MEDLINE    
A new antibiotic, okicenone was isolated from the culture broth of Streptomyces sp. KO-3599. The antibiotic possesses cytocidal activity against mammalian tumor cells in vitro at concentrations of 0.53-11.0 micrograms/ml whereas the antibiotic showed no antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1,000 micrograms/ml.
K Komiyama; S Funayama; Y Anraku; M Ishibashi; Y Takahashi; T Kawakami; S Omura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  44     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-10-25     Completed Date:  1991-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  814-8     Citation Subset:  IM    
Kitasato Institute, Tokyo, Japan.
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MeSH Terms
Anthracenes / isolation & purification,  therapeutic use
Antibiotics, Antineoplastic / isolation & purification*,  therapeutic use
Hela Cells / drug effects
Leukemia P388 / drug therapy
Lung Neoplasms / drug therapy
Melanoma, Experimental / drug therapy
Microbial Sensitivity Tests
Streptomyces / chemistry*
Tumor Cells, Cultured / drug effects
Reg. No./Substance:
0/Anthracenes; 0/Antibiotics, Antineoplastic; 137018-54-3/okicenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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