| A new animal model for the imaging of melanoma: correlation of FDG PET with clinical outcome, macroscopic aspect and histological classification in Melanoblastoma-bearing Libechov Minipigs. | |
| | |
MedLine Citation:
|
PMID: 12682788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to evaluate the Melanoblastoma-bearing Libechov Minipigs (MeLiM) as an animal model of melanoma for in vivo imaging. Serial whole-body 2-deoxy-2-[(18)F]fluoro- d-glucose positron emission tomography (FDG PET) scans were conducted on five MeLiM. In order to explore different clinical stages of the tumoural lesions, each animal was scanned two to four times, at intervals of 30-155 days. PET images were analysed by a semiquantitative method based on the tumour to muscle metabolic ratio. Histology was performed on biopsies taken between or after the scans and the histological grading of the tumours was compared with the FDG uptake. The overall sensitivity of FDG PET for the detection of cutaneous melanoma was 75%; 62.5% of involved lymph nodes were positive. Sensitivity was better for tumours with vertical growth than for flat lesions. FDG PET did not detect tumours with epidermal involvement only, nor did it detect small metastatic foci. The metabolic ratio was correlated with the evolution of the melanoma. FDG PET is effective in the staging of cutaneous melanoma and the follow-up of tumoural extension and regression in Melanoblastoma-bearing Libechov Minipigs. The results obtained in this animal model correlate well with those described in human melanoma. Accordingly, this model may be useful in testing new tracers specific for melanoma and in helping to detect molecules expressed early during tumoural regression. |
| | |
Authors:
|
Raphaël Boisgard; Silvia Vincent-Naulleau; Jean-Jacques Leplat; Stephan Bouet; Catherine Le Chalony; Yves Tricaud; Vratislav Horak; Claudine Geffrotin; Gérard Frelat; Bertrand Tavitian |
Related Documents
:
|
12067968 - 3-deoxy-3-[(18)f]fluorothymidine-positron emission tomography for noninvasive assessmen... 459028 - Pelvic lipomatosis: diagnosis using computed tomography. 19623408 - 18f-fdg pet for detecting metastases and synchronous primary malignancies in patients w... 20490488 - 18f-fdg pet/ct in the characterization and surgical decision concerning adrenal masses:... 19085038 - Muesothelial cyst of the spermatic cord as a cause of acquired cryptorchidism. 9500648 - Utility of thin-layer preparations in thyroid fine-needle aspiration: diagnostic accura... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-04-08 |
Journal Detail:
|
Title: European journal of nuclear medicine and molecular imaging Volume: 30 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2003 Jun |
Date Detail:
|
Created Date: 2003-05-27 Completed Date: 2004-03-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
|
Languages: eng Pagination: 826-34 Citation Subset: IM |
Affiliation:
|
Laboratoire d'imagerie de l'expression des gènes, CEA, Service hospitalier Frédéric Joliot, INSERM 0103, Orsay, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Disease Models, Animal Fluorodeoxyglucose F18 / diagnostic use*, pharmacokinetics Melanoma / pathology, radionuclide imaging, veterinary* Neoplasm Staging Radiopharmaceuticals / diagnostic use*, pharmacokinetics Skin Neoplasms / pathology, radionuclide imaging, veterinary* Swine Swine Diseases / pathology, radionuclide imaging* Swine, Miniature Tomography, Emission-Computed / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Durable complete clinical responses in a phase I/II trial using an autologous melanoma cell/dendriti...
Next Document: Benefit of anatomical-functional image fusion in the diagnostic work-up of neuroendocrine neoplasms.