Document Detail


A new alkaloid and other anti-implantation principles from Tabernaemontana heyneana.
MedLine Citation:
PMID:  11509989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new alkaloid designated as ervatine, in addition to seven known alkaloids, viz. tabersonine, coronaridine, heyneanine, voacristine, voacristine hydroxyindolenine, hydroxyibogamine, and coronaridine hydroxyindolenine, were isolated from the fruit of Tabernaemontana heyneana Wall. Characterisation and structure elucidation of these compounds was made on the basis of their spectral analyses. The ethanolic extract and isolated alkaloids heyneanine and voacristine prevented pregnancy when administered during the preimplantation period in Sprague-Dawley rats. These were, however, found to possess significant uterotrophic activity.
Authors:
S Srivastava; M M Singh; D K Kulshreshtha
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Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Planta medica     Volume:  67     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-17     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  577-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alkaloids / chemistry,  isolation & purification*,  pharmacology
Angiosperms / chemistry*
Animals
Embryo Implantation / drug effects*
Fruit / chemistry
India
Indole Alkaloids / chemistry,  isolation & purification*,  pharmacology
Magnetic Resonance Spectroscopy
Plant Extracts / pharmacology
Plants, Medicinal
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Indole Alkaloids; 0/Plant Extracts; 0/ervatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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