Document Detail

A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish.
MedLine Citation:
PMID:  21050179     Owner:  NLM     Status:  MEDLINE    
Recently, extracellular RNases of the RNase A superfamily, with the characteristic CKxxNTF sequence signature, have been identified in fish. This has led to the recognition that these RNases are present in the whole vertebrate subphylum. In fact, they comprise the only enzyme family unique to vertebrates. Four RNases from zebrafish (Danio rerio) have been previously reported and have a very low RNase activity; some of these are endowed, like human angiogenin, with powerful angiogenic and bactericidal activities. In the present paper, we report the three-dimensional structure, the thermodynamic behaviour and the biological properties of a novel zebrafish RNase, ZF-RNase-5. The investigation of its structural and functional properties, extended to all other subfamily members, provides an inclusive description of the whole zebrafish RNase subfamily.
Elio Pizzo; Antonello Merlino; Mimmo Turano; Irene Russo Krauss; Francesca Coscia; Anna Zanfardino; Mario Varcamonti; Adriana Furia; Concetta Giancola; Lelio Mazzarella; Filomena Sica; Giuseppe D'Alessio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  433     ISSN:  1470-8728     ISO Abbreviation:  Biochem. J.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-23     Completed Date:  2011-01-24     Revised Date:  2011-09-06    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  England    
Other Details:
Languages:  eng     Pagination:  345-55     Citation Subset:  IM    
Dipartimento di Biologia Strutturale e Funzionale, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, Naples, Italy.
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MeSH Terms
Amino Acid Sequence
Cells, Cultured
Gene Expression Regulation, Developmental
Gene Expression Regulation, Enzymologic
Models, Molecular
Molecular Sequence Data
Protein Structure, Tertiary
Ribonuclease, Pancreatic / chemistry*,  genetics,  metabolism
Ribonucleases / chemistry*,  genetics,  metabolism
Sequence Alignment
Zebrafish / embryology,  genetics,  metabolism*
Reg. No./Substance:
EC 3.1.-/Ribonucleases; EC 3.1.27.-/angiogenin; EC, Pancreatic

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