Document Detail


A new 18F-labeled myocardial PET tracer: myocardial uptake after permanent and transient coronary occlusion in rats.
MedLine Citation:
PMID:  18794259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Conventional myocardial perfusion PET tracers require onsite tracer production because of their short radioactive half-lives. To investigate the potential of a new (18)F-labeled pyridazinone analog ((18)F-BMS-747158-02), we characterized this tracer in a rat model of permanent and transient coronary occlusion using small-animal PET. METHODS: Myocardial (18)F-BMS-747158-02 distribution in healthy rats (n = 7), rats with transient (3-min) left coronary artery occlusion (n = 11), and rats with permanent left coronary occlusion (n = 11) was analyzed with a dedicated small-animal PET scanner. RESULTS: Normal hearts demonstrated intense and almost homogeneous tracer uptake throughout the left ventricle for more than 2 h. During permanent coronary occlusion, PET demonstrated perfusion defects, which remained unchanged (37.6% +/- 8.8%, 37.4% +/- 10.2%, and 36.2% +/- 9.8% left ventricle at 15, 45, and 115 min, respectively, after tracer injection). After transient ischemia, the induced defect size decreased significantly after reperfusion (16.2% +/- 9.3%, 6.0% +/- 6.5%, and 1.4% +/- 1.3% left ventricle). Tracer reinjection after transient ischemia resulted in normalization of the induced defect. CONCLUSION: Coronary occlusion yielded distinct myocardial (18)F-BMS-747158-02 uptake defects in the area of ischemia, which demonstrated normalization of activity after reperfusion and reinjection. These promising kinetic parameters may allow for assessment of flow using exercise-rest protocols similar to those used in combination with exercise and rest perfusion SPECT.
Authors:
Takahiro Higuchi; Stephan G Nekolla; Marc M Huisman; Sybille Reder; Thorsten Poethko; Ming Yu; Hans-Jurgen Wester; David S Casebier; Simon P Robinson; Rene M Botnar; Markus Schwaiger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-15
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  49     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-03     Completed Date:  2008-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1715-22     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany. higuchi@po2.nsknet.or.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Occlusion / pathology,  radionuclide imaging*
Fluorine Radioisotopes / pharmacokinetics*
Heart / radionuclide imaging*
Heart Ventricles / pathology
Ischemia / pathology
Kinetics
Male
Myocardium / metabolism
Positron-Emission Tomography / instrumentation,  methods*
Pyridazines / pharmacokinetics*
Radiopharmaceuticals / pharmacokinetics*
Rats
Rats, Wistar
Reperfusion Injury
Chemical
Reg. No./Substance:
0/BMS 747158-02; 0/Fluorine Radioisotopes; 0/Pyridazines; 0/Radiopharmaceuticals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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