Document Detail


The neurovascular link in health and disease: an update.
MedLine Citation:
PMID:  19801203     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the nervous and vascular systems are functionally different, they show a high degree of anatomic parallelism and cross-talk. They also share similar mechanisms and molecular cues that regulate their development and maintenance. Malfunctioning of this cross-talk can cause or influence several vascular and neuronal disorders. In this review, we first provide a brief overview of the molecular and cellular mechanisms that govern the neurovascular link. Second, we focus on two neurodegenerative diseases, Alzheimer's disease and amyotrophic lateral sclerosis, to illustrate how a defective neurovascular link might contribute to their pathogenesis. Finally, we briefly discuss some therapeutic implications of the neurovascular link for designing strategies to treat these diseases.
Authors:
Inmaculada Segura; Frederik De Smet; Philipp J Hohensinner; Carmen Ruiz de Almodovar; Peter Carmeliet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-10-02
Journal Detail:
Title:  Trends in molecular medicine     Volume:  15     ISSN:  1471-499X     ISO Abbreviation:  Trends Mol Med     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-26     Completed Date:  2010-01-06     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  100966035     Medline TA:  Trends Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  439-51     Citation Subset:  IM    
Affiliation:
Vesalius Research Center (VRC), VIB, Leuven, 3000, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Animals
Health*
Humans
Nervous System / blood supply*,  metabolism,  pathology
Neurodegenerative Diseases / pathology*,  therapy

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