| The neurotoxicity of industrial solvents: a review of the literature. | |
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MedLine Citation:
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PMID: 3901738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Organic solvents, particularly stryrene, are used widely in boatbuilding. They may be absorbed by workers either through the respiratory tract or the skin. Uptake is influenced by level and duration of exposure, work load, and specific physiochemical features of each solvent, as well as by work practices and use of protective equipment. Kinetics of metabolism and excretion kinetics are highly variable among compounds. Metabolites can be measured in blood, urine, or exhaled breath and may serve as indirect indices of absorption. Acute high-dose exposure to organic solvents can produce a transient narcotic effect on the central nervous system. This effect occurs in proportion to brain dose, which in turn is determined by intensity and duration of exposure. Additionally, chronic exposures to organic solvents have been reported to produce an increased frequency of neurologic signs and symptoms. These findings include peripheral neuropathies and toxic encephalopathies. The latter are characterized by alterations in affect, memory loss, and impaired cognition. Concern exists that prolonged excessive exposure to organic solvents may lead to premature and persistent dementia in certain workers. |
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Authors:
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E L Baker; T J Smith; P J Landrigan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: American journal of industrial medicine Volume: 8 ISSN: 0271-3586 ISO Abbreviation: Am. J. Ind. Med. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-10-25 Completed Date: 1985-10-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8101110 Medline TA: Am J Ind Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 207-17 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Maximum Allowable Concentration Nervous System Diseases / chemically induced*, prevention & control Occupational Diseases / chemically induced*, prevention & control Occupations Ships* Skin Absorption Solvents / metabolism, toxicity* Styrene Styrenes / metabolism, toxicity* |
| Grant Support | |
ID/Acronym/Agency:
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ES00002-21/ES/NIEHS NIH HHS; K010H00043//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Solvents; 0/Styrenes; 100-42-5/Styrene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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