Document Detail

The neurosteroid pregnenolone sulphate increases dopamine release and the dopaminergic response to morphine in the rat nucleus accumbens.
MedLine Citation:
PMID:  10564382     Owner:  NLM     Status:  MEDLINE    
Neurosteroids are a subclass of steroids that can be synthesized in the central nervous system independently of peripheral sources. Clinical studies in humans have associated some of these hormones with a generic sensation of 'well-being' and with pathologies such as depression. In rodents, the neurosteroid pregnenolone sulphate (Preg-S) has been shown to present antidepressant-like effects. These observations suggest that neurosteroids could interact with reward-related processes, mood and motivation. However, the possible neural substrates of such an effect remain unclear. In this report, we studied the action of Preg-S on the activity of the mesencephalic dopaminergic projection to the nucleus accumbens which is considered one of the biological substrates of motivation and reward. Both the direct effect of Preg-S and the influence of this hormone on the dopaminergic response to the pharmacological reward provided by the opiate morphine, were studied by means of microdialysis. Pregnenolone sulphate dose-dependently increased dopamine release in the nucleus accumbens. Furthermore, this hormone doubled the dopaminergic response to morphine. These effects were observed for Preg-S doses of 100, 200, and 400 pmol injected intracerebroventricularly. The stimulant effect of Preg-S on dopamine could mediate some of the behavioural effects of neurosteroids and in particular the interaction of these hormones with mood and motivation.
M Barrot; M Vallée; M A Gingras; M Le Moal; W Mayo; P V Piazza
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  11     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-08     Completed Date:  1999-12-08     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  3757-60     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Affect / drug effects,  physiology
Dopamine / metabolism*
Injections, Intraventricular
Morphine / pharmacology*
Narcotics / pharmacology*
Nucleus Accumbens / drug effects*,  metabolism
Pregnenolone / pharmacology*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Narcotics; 1247-64-9/pregnenolone sulfate; 73R90F7MQ8/Pregnenolone; 76I7G6D29C/Morphine; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Experience-dependent increase in cAMP-responsive element binding protein in synaptic and nonsynaptic...
Next Document:  Human striosomes are enriched in 5-HT2A receptors: autoradiographical visualization with [3H]MDL100,...