Document Detail


The neurosteroid 3alphaDIOL modulates place preference when infused in the basolateral amygdala according to sex.
MedLine Citation:
PMID:  16768615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three different behavioral tasks were used to study the role of the neurosteroid 5alpha -androstane-3alpha, 17beta-diol (3alphaDIOL) in affective components of behavior when infused into the basolateral amygdala (BLA) of both sexes. Female rats were ovariectomized; half received implants containing estradiol benzoate (OVX-EB), whereas the other half received empty implants (OVX). Male rats were gonadally intact. No differences were noted in male behavior according to the conditioned place preference (CPP) test, the modified Vogel conflict test (VCT), or the elevated plus maze (EPM) upon infusion of 3alphaDIOL. In contrast, 3alphaDIOL modulated CPP and VCT performance among female rats. Therefore, the authors propose that 3alphaDIOL modulates affect through the BLA via a sex-specific mechanism.
Authors:
Nivia L Pérez-Acevedo; Liselle Lathroum; Juan Carlos Jorge
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  120     ISSN:  1939-0084     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2009-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  632-40     Citation Subset:  IM    
Copyright Information:
Copyright 2006 APA, all rights reserved.
Affiliation:
Department of Anatomy, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
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MeSH Terms
Descriptor/Qualifier:
Amygdala / drug effects*
Analysis of Variance
Animals
Behavior, Animal / drug effects,  physiology
Conditioning, Operant / drug effects*
Estradiol / analogs & derivatives*,  pharmacology
Estrogens / blood,  pharmacology
Exploratory Behavior / drug effects
Female
GABA Agonists / pharmacology
GABA Antagonists / pharmacology
Male
Maze Learning / drug effects
Motor Activity / drug effects
Muscimol / pharmacology
Ovariectomy / methods
Pyridazines / pharmacology
Radioimmunoassay / methods
Rats
Rats, Sprague-Dawley
Sex Characteristics*
Spatial Behavior / drug effects*
Steroids / pharmacology
Grant Support
ID/Acronym/Agency:
G12RR03051/RR/NCRR NIH HHS; GM61838/GM/NIGMS NIH HHS; RR15565/RR/NCRR NIH HHS; RR16470/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Estrogens; 0/GABA Agonists; 0/GABA Antagonists; 0/Pyridazines; 0/Steroids; 104104-50-9/gabazine; 2763-96-4/Muscimol; 50-28-2/Estradiol; 50-50-0/estradiol 3-benzoate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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