Document Detail

The neuropsychology of patients with clinically diagnosed idiopathic normal pressure hydrocephalus.
MedLine Citation:
PMID:  18162901     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the neuropsychological performance of patients with idiopathic normal pressure hydrocephalus (INPH) with that of healthy individuals and to examine its relation to neurological signs, vascular comorbidity, and background factors. METHODS: A consecutive series of 58 patients with INPH underwent neurological, neuroradiological, and neuropsychological examinations. The neuropsychological tests, measuring vigilance, fine movements of the hands, learning, working memory, and aspects of executive functioning, were also administered to 108 healthy individuals. RESULTS: Patients performed worse than healthy individuals on all included tests. Significant correlations between test results were more frequent and stronger among patients and the degree of neuropsychological impairment was related to the severity of other signs of INPH. Patients with vascular risk factors performed worse than those without. CONCLUSION: The neuropsychological deficits in INPH are widely distributed, interrelated, associated with neurological signs, and aggravated by vascular comorbidity.
Per Hellström; Mikael Edsbagge; Trevor Archer; Magnus Tisell; Mats Tullberg; Carsten Wikkelsø
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  61     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-28     Completed Date:  2008-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1219-26; discussion 1227-8     Citation Subset:  IM    
Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden.
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MeSH Terms
Aged, 80 and over
Hydrocephalus, Normal Pressure / diagnosis,  surgery*
Middle Aged
Neuropsychological Tests / statistics & numerical data
Neuropsychology / methods*
Retrospective Studies
Statistics, Nonparametric
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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