Document Detail

The neuropsychological profile of children at high risk of developing an eating disorder.
MedLine Citation:
PMID:  23021014     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is a large body of evidence indicating that eating disorders (EDs) are characterized by particular neuropsychological profiles. We aimed to further explore whether impairments in neuropsychological functioning previously found in ED groups are present prior to onset, or are secondary to the disorder. Method This is the first study to explore neuropsychological functioning in children born to a mother with a lifetime ED, who are therefore at high risk of developing an ED, in a large cohort sample. We investigated intelligence and attention at age 8 years (n = 6201) and working memory (WM) and inhibition at age 10 years (6192) in children who are at high risk of developing an ED, compared to children who are not.
RESULTS: The children of women with lifetime anorexia nervosa (AN) showed high full-scale and performance IQ, increased WM capacity, better visuo-spatial functioning, and decreased attentional control. The children of women with lifetime bulimia nervosa (BN) showed comparatively poor visuo-spatial functioning.
CONCLUSIONS: Our findings suggest that high intelligence, increased WM capacity and impaired attentional control might be intermediate phenotypes on the pathway between genetic vulnerability and the development of an ED.
R Kothari; F Solmi; J Treasure; N Micali
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-01
Journal Detail:
Title:  Psychological medicine     Volume:  43     ISSN:  1469-8978     ISO Abbreviation:  Psychol Med     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-17     Completed Date:  2014-02-17     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1543-54     Citation Subset:  IM    
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MeSH Terms
Anorexia Nervosa / genetics,  physiopathology,  psychology*
Bulimia Nervosa / genetics,  physiopathology,  psychology*
Child of Impaired Parents / psychology*
Cohort Studies
Executive Function
Genetic Predisposition to Disease
Inhibition (Psychology)
Memory, Short-Term*
Neuropsychological Tests
Risk Factors
Grant Support
CS/08/08/14//Department of Health; //Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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