Document Detail

The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice.
MedLine Citation:
PMID:  14508320     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Xenon has been shown to be neuroprotective in several models of in vitro and in vivo neuronal injury. However, its putative neuroprotective properties have not been evaluated in focal cerebral ischemia. The purpose of this study was to determine if xenon offers neuroprotection in a mouse model of middle cerebral artery occlusion. METHODS: C57BL/6 mice underwent 60 min of middle cerebral artery occlusion. The animals (n = 21 per group) were randomized to receive either 70% xenon + 30% O2, 70% N2O + 30% O2, or 35% xenon + 35% N2O + 30% O2. After 24 h, functional neurologic outcome (on three independent scales: four-point, general, and focal deficit scales) and cerebral infarct size were evaluated. RESULTS: The 70% xenon + 30% O2 group showed improved functional outcome (median [interquartile range], four-point scale: 2 [2], 70% xenon + 30% O2 versus 3 [2], 70% N2O + 30% O2, P = 0.0061; general deficit scale: 9 [6], 70% xenon + 30% O2 versus 10 [4], 70% N2O + 30% O2, P = 0.0346). Total cerebral infarct volumes were reduced in the 70% xenon + 30% O2 group compared with the 70% N2O + 30% O2 group (45 +/- 17 mm3 versus 59 +/- 11 mm3, respectively; P = 0.0009). CONCLUSIONS: In this model of transient focal cerebral ischemia, xenon administration improved both functional and histologic outcome.
H Mayumi Homi; Noriko Yokoo; Daqing Ma; David S Warner; Nicholas P Franks; Mervyn Maze; Hilary P Grocott
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  99     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-25     Completed Date:  2003-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  876-81     Citation Subset:  AIM; IM    
Department of Anesthesiology (Multidisciplinary Neuroprotection Laboratories), Duke University Medical Center, Durham, North Carolina, USA.
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MeSH Terms
Administration, Inhalation
Infarction, Middle Cerebral Artery / drug therapy*,  physiopathology
Ischemic Attack, Transient / drug therapy,  physiopathology
Mice, Inbred C57BL
Neuroprotective Agents / administration & dosage*
Xenon / administration & dosage*
Reg. No./Substance:
0/Neuroprotective Agents; 7440-63-3/Xenon
Comment In:
Anesthesiology. 2004 Jul;101(1):260-1; author reply 261   [PMID:  15220810 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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