| The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions. | |
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MedLine Citation:
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PMID: 14597564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypothalamic neuropeptide Y (NPY) plays a central role in the control of food intake, energy balance, and modulation of neuroendocrine functions. In particular, an increase in NPY expression participates in the inhibition of the reproductive activity under poor nutritional conditions. The present study was designed to evaluate further the involvement of the Y1 subtype of NPY receptors in these effects. Food intake, body weight gain, and the onset of puberty were studied in groups of wild-type and Y1 deficient mice that were either fed ad libitum or subjected to a 30% restriction in food intake. This moderate feeding restriction induced a similar deficit in body weight gain in wild-type and in Y1 knockout mice. However, although wild-type mice experienced the expected delay of puberty, all mice in the food restriction group and lacking Y1 could go through puberty over the time of the experiment despite decreases in circulating leptin levels and increases in hypothalamic NPY expression. This observation demonstrates that the absence of Y1 impairs the perception of decreasing energy stores by the gonadotrope axis, demonstrating a physiological role for Y1 in the sensing of endogenous metabolic parameters by the hypothalamus. |
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Authors:
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Christine Gonzales; Marie-Jeanne Voirol; Marco Giacomini; Rolf C Gaillard; Thierry Pedrazzini; François P Pralong |
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Publication Detail:
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Type: Journal Article Date: 2003-11-03 |
Journal Detail:
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Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 18 ISSN: 1530-6860 ISO Abbreviation: FASEB J. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-13 Completed Date: 2004-02-09 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: United States |
Other Details:
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Languages: eng Pagination: 137-9 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Caloric Restriction Eating Female Gonadotropins / analysis Hypothalamus / physiology* Mice Mice, Knockout Neuropeptide Y / genetics, physiology* Neurosecretory Systems / physiology Receptors, Neuropeptide Y / physiology* Sexual Maturation / physiology* Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Gonadotropins; 0/Neuropeptide Y; 0/Receptors, Neuropeptide Y; 0/neuropeptide Y-Y1 receptor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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