Document Detail


The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions.
MedLine Citation:
PMID:  14597564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypothalamic neuropeptide Y (NPY) plays a central role in the control of food intake, energy balance, and modulation of neuroendocrine functions. In particular, an increase in NPY expression participates in the inhibition of the reproductive activity under poor nutritional conditions. The present study was designed to evaluate further the involvement of the Y1 subtype of NPY receptors in these effects. Food intake, body weight gain, and the onset of puberty were studied in groups of wild-type and Y1 deficient mice that were either fed ad libitum or subjected to a 30% restriction in food intake. This moderate feeding restriction induced a similar deficit in body weight gain in wild-type and in Y1 knockout mice. However, although wild-type mice experienced the expected delay of puberty, all mice in the food restriction group and lacking Y1 could go through puberty over the time of the experiment despite decreases in circulating leptin levels and increases in hypothalamic NPY expression. This observation demonstrates that the absence of Y1 impairs the perception of decreasing energy stores by the gonadotrope axis, demonstrating a physiological role for Y1 in the sensing of endogenous metabolic parameters by the hypothalamus.
Authors:
Christine Gonzales; Marie-Jeanne Voirol; Marco Giacomini; Rolf C Gaillard; Thierry Pedrazzini; François P Pralong
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Publication Detail:
Type:  Journal Article     Date:  2003-11-03
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  18     ISSN:  1530-6860     ISO Abbreviation:  FASEB J.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-13     Completed Date:  2004-02-09     Revised Date:  2012-02-15    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  137-9     Citation Subset:  IM    
Affiliation:
Division of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Caloric Restriction
Eating
Female
Gonadotropins / analysis
Hypothalamus / physiology*
Mice
Mice, Knockout
Neuropeptide Y / genetics,  physiology*
Neurosecretory Systems / physiology
Receptors, Neuropeptide Y / physiology*
Sexual Maturation / physiology*
Weight Gain
Chemical
Reg. No./Substance:
0/Gonadotropins; 0/Neuropeptide Y; 0/Receptors, Neuropeptide Y; 0/neuropeptide Y-Y1 receptor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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