Document Detail


The neuropathology of kernicterus in the premature neonate: diagnostic problems.
MedLine Citation:
PMID:  6693927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Yellow staining of central nervous system (CNS) nuclei occurs in the brains of some neonates, despite low levels of serum bilirubin. Two conditions appear to be important in the evolution of this form of kernicterus: prematurity and asphyxia. In a seven year retrospective study of a large neonatal autopsy population, 102 cases had kernicterus as indicated by selective macroscopic yellow staining and microscopic damage within specific CNS nuclei. Neuropathological study disclosed minor variations and numerous similarities in the manifestations of kernicterus in the asphyctic premature neonate with low levels of serum bilirubin, as compared to kernicterus in the full-term neonate with high levels of serum bilirubin. Acidosis, hypoxia, hyperoxia, hypothermia and sepsis have been considered significant risk factors, but recent comparative clinical studies have not defined predictive indices. Analysis of this disorder is difficult because of the concurrence of other complications of asphyxia and its pathological correlates in premature infants. Diagnostic difficulties are also compounded by variations in the definitions of kernicterus as used by different investigators.
Authors:
M Ahdab-Barmada; J Moossy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuropathology and experimental neurology     Volume:  43     ISSN:  0022-3069     ISO Abbreviation:  J. Neuropathol. Exp. Neurol.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-03-12     Completed Date:  1984-03-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985192R     Medline TA:  J Neuropathol Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-56     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Asphyxia Neonatorum / pathology
Bilirubin / blood
Brain / pathology*
Cytoplasm / ultrastructure
Diagnosis, Differential
Gestational Age
Humans
Infant, Newborn
Infant, Premature, Diseases / blood,  pathology*
Kernicterus / blood,  pathology*
Neurons / pathology
Retrospective Studies
Chemical
Reg. No./Substance:
635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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