Document Detail

The neuropathological contribution of prenatal inflammation to schizophrenia.
MedLine Citation:
PMID:  21158552     Owner:  NLM     Status:  In-Process    
Maternal infection and/or inflammation during pregnancy has been repeatedly shown to elevate the risk of schizophrenia and related psychotic disorders in offspring. However, the relative contribution of such immune-related prenatal insults to specific neuropathological outcomes in schizophrenia remains essentially unknown. The study by Ellman et al. is the first to explore whether prenatal levels of the proinflammatory cytokine, IL-8, are associated with the volume of specific brain regions in patients diagnosed with schizophrenia spectrum disorder. The authors provide new data to support a significant association between higher prenatal IL-8 levels in the second/third trimester of pregnancy and greater ventricular cerebrospinal fluid volume in adult schizophrenia spectrum cases. In addition, the results provide evidence for a significant relationship between higher prenatal IL-8 levels and lower volumes in the left entorhinal cortex and right posterior cingulate. The findings provided by Ellman et al., together with the results obtained in other epidemiological studies and experimental animal research, should encourage basic researchers and clinicians alike to make efforts towards the investigation of maternal immunomodulatory interventions that may help alleviate abnormal brain development and long-term psychotic illness in offspring.
Urs Meyer; Ina Weiner; Grainne M McAlonan; Joram Feldon
Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Expert review of neurotherapeutics     Volume:  11     ISSN:  1744-8360     ISO Abbreviation:  Expert Rev Neurother     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129944     Medline TA:  Expert Rev Neurother     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-32     Citation Subset:  -    
Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology, Zurich, Switzerland.
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MeSH Terms
Comment On:
Schizophr Res. 2010 Aug;121(1-3):46-54   [PMID:  20553865 ]

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