| The neuropathological basis of clinical progression in multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 21626034 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Multiple sclerosis is the major inflammatory condition affecting the central nervous system (CNS) and is characterised by disseminated focal immune-mediated demyelination. Demyelination is accompanied by variable axonal damage and loss and reactive gliosis. It is this pathology that is thought to be responsible for the clinical relapses that often respond well to immunomodulatory therapy. However, the later secondary progressive stage of MS remains largely refractory to treatment and it is widely suggested that accumulating axon loss is responsible for clinical progression. Although initially thought to be a white matter (WM) disease, it is increasingly apparent that extensive pathology is also seen in the grey matter (GM) throughout the CNS. GM pathology is characterised by demyelination in the relative absence of an immune cell infiltrate. Neuronal loss is also seen both in the GM lesions and in unaffected areas of the GM. The slow progressive nature of this later stage combined with the presence of extensive grey matter pathology has led to the suggestion that neurodegeneration might play an increasing role with increasing disease duration. However, there is a paucity of studies that have correlated the pathological features with clinical milestones during secondary progressive MS. Here, we review the contributions that the various types of pathology are likely to make to the increasing neurological deficit in MS. |
| | |
Authors:
|
Richard Reynolds; Federico Roncaroli; Richard Nicholas; Bishan Radotra; Djordje Gveric; Owain Howell |
Related Documents
:
|
15585304 - A novel negative regulator for il-1 receptor and toll-like receptor 4. 19017994 - Socs1 regulates the ifn but not nfkappab pathway in tlr-stimulated human monocytes and ... 15743884 - Local coordination verses systemic disregulation: complexities in leukocyte recruitment... 19382314 - Murine mast cells secrete a unique profile of cytokines and prostaglandins in response ... 21878234 - Bile salt supplementation acts via the farnesoid x receptor to alleviate lipopolysaccha... 7797124 - Constitutive and cytokine induced expression of hla molecules, secretory component, and... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-28 |
Journal Detail:
|
Title: Acta neuropathologica Volume: - ISSN: 1432-0533 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0412041 Medline TA: Acta Neuropathol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Wolfson Neuroscience Laboratories, Division of Experimental Medicine, UK Multiple Sclerosis Tissue Bank, Centre for Neuroscience, Imperial Faculty of Medicine College London, Hammersmith Hospital Campus, London, W12 0NN, UK, r.reynolds@imperial.ac.uk. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Targeting the extrinsic apoptosis signaling pathway for cancer therapy.
Next Document: Vasculitis-like neuropathy in amyotrophic lateral sclerosis unresponsive to treatment.