Document Detail

A neuronal nitric oxide synthase inhibitor 7-nitroindazole reduces the 5-HT1A receptor against 8-OH-DPAT-elicited hyperphagia in rats.
MedLine Citation:
PMID:  10440082     Owner:  NLM     Status:  MEDLINE    
The effects of the neuronal nitric oxide (NO) synthase inhibitor 7-nitroindazole on 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT)-induced hyperphagia, which is mediated by the 5-HT1A autoreceptor, were investigated in rats. 7-Nitroindazole suppressed 8-OH-DPAT-elicited increases in food intake. The inhibitory effects of 7-nitroindazole on 8-OH-DPAT-induced feeding were prevented by the NO precursor L-arginine. Although 8-OH-DPAT decreases 5-hydroxytryptamine (5-HT) synthesis, 7-nitroindazole did not reverse the 8-OH-DPAT-elicited decrease in 5-HT synthesis. Therefore, these results indicate that NO formed in the brain is involved in 8-OH-DPAT-induced hyperphagia and that the hypophagic effects of 7-nitroindazole are not dependent on 5-HT synthesis.
Y Sugimoto; J Yamada; T Yoshikawa
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  376     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-27     Completed Date:  1999-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Department of Pharmacology, Kobe Pharmaceutical University, Japan.
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MeSH Terms
8-Hydroxy-2-(di-n-propylamino)tetralin / toxicity
Arginine / pharmacology
Autoreceptors / agonists*
Enzyme Inhibitors / pharmacology*
Feeding Behavior / drug effects
Hyperalgesia / chemically induced,  metabolism*,  physiopathology*
Hypothalamus / drug effects,  metabolism
Indazoles / pharmacology*
Neurons / enzymology
Nitric Oxide Synthase / antagonists & inhibitors*
Rats, Sprague-Dawley
Receptors, Serotonin / drug effects*
Receptors, Serotonin, 5-HT1
Serotonin / biosynthesis
Serotonin Agonists / toxicity
Reg. No./Substance:
0/Autoreceptors; 0/Enzyme Inhibitors; 0/Indazoles; 0/Receptors, Serotonin; 0/Receptors, Serotonin, 5-HT1; 0/Serotonin Agonists; 2942-42-9/7-nitroindazole; 50-67-9/Serotonin; 74-79-3/Arginine; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin; EC Oxide Synthase

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