Document Detail

Is neuromuscular relaxation of rocuronium prolonged in patients with obstructive jaundice?
MedLine Citation:
PMID:  20832951     Owner:  NLM     Status:  In-Process    
Rocuronium is an aminosteroid non-depolarizing neuromuscular relaxant, which is metabolized in the liver and excreted through bile. The duration of neuromuscular blockade of rocuronium at equipotent bolus dose may be prolonged and variable in patients with liver and kidney failure. However, very few studies have been reported its pharmacodynamics in patients with obstructive jaundice. We propose that the effect of rocuronium is prolonged in patients with obstructive jaundice, and a caution should be taken in monitoring postoperative residual neuromuscular blockade.
Zhenmeng Wang; Yang Bao; Zhijie Lu; WeiFeng Yu
Publication Detail:
Type:  Journal Article     Date:  2010-09-15
Journal Detail:
Title:  Medical hypotheses     Volume:  76     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  100-1     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Department of Anesthesia and Intensive Care, Eastern Hepatobiliary Surgery Hospital, 225# Changhai Road, Shanghai 200438, China.
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