| The neurology of human immunodeficiency virus infection. | |
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MedLine Citation:
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PMID: 2855754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HIV-infected patients are at markedly increased risk for neurological dysfunction, which may occur at any level of the neuraxis (see Table 1). The most common syndromes--AIDS dementia complex, vacuolar myelopathy, and possibly distal symmetric peripheral neuropathy--appear to be related to HIV infection within the nervous system, rather than due to the immunoincompetence caused by HIV. However, the mechanism(s) by which HIV causes these syndromes, e.g., infecting neurons or oligodendroglia directly, interfering with neurotrophic factors, effecting toxic monokine production, etc., is unknown. Early, albeit incomplete, success with azidothymidine is encouraging. Less commonly, neurological syndromes may be secondary to the immunoincompetence produced by HIV. Many different etiologies--most of which are treatable--have been encountered, but a few of these (cerebral toxoplasmosis, cryptococcal meningitis, primary CNS lymphoma, and progressive multifocal leukoencephalopathy) are responsible for most of the opportunistic complications. Marked differences in symptoms and signs between AIDS patients and immunologically normal patients may complicate recognition of some of these diseases (e.g., herpes simplex encephalitis). Finally, some HIV-associated syndromes, e.g., inflammatory demyelinating polyradiculoneuropathy and retinal microvasculopathy, are of unknown etiology. |
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Authors:
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D E Bredesen; R M Levy; M L Rosenblum |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Quarterly journal of medicine Volume: 68 ISSN: 0033-5622 ISO Abbreviation: Q. J. Med. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1989-10-18 Completed Date: 1989-10-18 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0401027 Medline TA: Q J Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 665-77 Citation Subset: IM; X |
Affiliation:
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Department of Neurology, University of California School of Medicine, San Francisco. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications* Dementia / etiology Humans Nervous System Diseases / etiology* Opportunistic Infections / complications Peripheral Nervous System Diseases / etiology |
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