Document Detail

The neuroleptic malignant syndrome: a report of 14 cases from North India.
MedLine Citation:
PMID:  17558126     Owner:  NLM     Status:  MEDLINE    
Neuroleptic malignant syndrome (NMS) is a rare, life-threatening but potentially treatable condition. This study was performed to investigate the clinical spectrum, antecedent events and outcome of NMS patients admitted in the Neurology department of a large teaching hospital of North India. Fourteen cases of NMS were taken after a thorough search during a three-year period (May 2000 to April 2003). The Incidence of NMS was 1.40/ 1000 patients treated with neuroleptics and mortality rate was 14.28%. Amongst the neuroleptics Haloperidol (parenteral) was implicated as a most common drug for NMS in 57% of patients. An association with coexisting precipitating illness was clearly recorded in 71.4% patients. All the recorded patients of NMS received 500-700 mg CPZ equivalent/day of neuroleptics. NMS as an indiosyncratic phenomenon was noticed in 28% patients. 85.7% responded to dopaminergic drugs along with supportive treatment and showed partial or complete recovery within 7-14 days. In those with partial recovery residual deficits included Parkinsonian features, depression and diaphoresis in a small percentage of patients.
A Panagariya; B Sharma; R Singh; V Agarwal; A Dev
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology India     Volume:  55     ISSN:  0028-3886     ISO Abbreviation:  Neurol India     Publication Date:    2007 Apr-Jun
Date Detail:
Created Date:  2007-06-11     Completed Date:  2009-06-12     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0042005     Medline TA:  Neurol India     Country:  India    
Other Details:
Languages:  eng     Pagination:  166-8     Citation Subset:  IM    
Department of Neurology, SMS Medical College and Attached Hospitals, Jaipur, India.
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MeSH Terms
Antipsychotic Agents / adverse effects
Child, Preschool
Dopamine Agents / therapeutic use
Haloperidol / adverse effects
India / epidemiology
Middle Aged
Neuroleptic Malignant Syndrome / diagnosis,  epidemiology,  pathology*
Young Adult
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dopamine Agents; 52-86-8/Haloperidol

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