| A neurokinin 1 receptor antagonist decreases adhesion reformation after laparoscopic lysis of adhesions in a rat model of adhesion formation. | |
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MedLine Citation:
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PMID: 17356938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Up to 94% of patients experience fibrous adhesions after abdominal surgery, and a significant number of these patients require a second operation for open or laparoscopic lysis of adhesions (LOA). The authors have previously shown that inhibition of the binding of tachykinin ligands to the neurokinin 1 receptor (NK-1R) using the neurokinin 1 receptor antagonist (NK-1RA) CJ-12,255 decreases primary adhesion formation and upregulates the peritoneal fibrinolytic system in a rat model. Whereas most studies have focused on the prevention of primary adhesions, few have addressed adhesion reformation after LOA. This study aimed to determine the effects of NK-1RA administration on adhesion reformation and peritoneal fibrinolytic activity after laparoscopic LOA. METHODS: Adhesions were induced in 31 rats using our previously described ischemic button model. The rats underwent laparoscopy 7 days later, during which adhesions were scored and lysed followed by administration of the NK-1RA or saline. Then 7 days after LOA, 23 rats were killed and adhesions were scored. Eight rats also were killed 24 h after the LOA to obtain peritoneal tissue and fluid, which were analyzed for tissue plasminogen activator (tPA) mRNA expression and peritoneal fibrinolytic activity by reverse transcriptase-polymerase chain reaction (RT-PCR) and bioassay, respectively. RESULTS: At laparoscopy, 79% +/- 3% of the buttons formed adhesions. In the saline-administered control animals, 42% +/- 3.2% of the buttons reformed adhesions after LOA (p < 0.05), whereas in the animals that received the NK-1RA, 18.2% +/- 3.5% of the buttons reformed adhesions (p < 0.05). As compared with control animals, NK-1RA administration increased tPA mRNA levels by 38% and fibrinolytic activity sixfold (p < 0.05; 7.0 +/- 2.1 U/ml vs 1.2 +/- 0.54 U/ml). CONCLUSIONS: When administered during laparoscopic LOA, an NK-1RA significantly upregulates peritoneal fibrinolytic activity and decreases adhesion reformation. |
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Authors:
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S G Prushik; C B Aarons; R Matteotti; K L Reed; A C Gower; S E Leeman; A F Stucchi; J M Becker |
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Publication Detail:
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Type: Journal Article Date: 2007-03-14 |
Journal Detail:
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Title: Surgical endoscopy Volume: 21 ISSN: 1432-2218 ISO Abbreviation: Surg Endosc Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-13 Completed Date: 2007-10-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8806653 Medline TA: Surg Endosc Country: Germany |
Other Details:
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Languages: eng Pagination: 1790-5 Citation Subset: IM |
Affiliation:
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Department of Surgery, Boston University School of Medicine, 88 East Newton street, C500, Boston, MA 02118, USA. scott.prushik@bmc.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bicyclo Compounds, Heterocyclic / therapeutic use* Disease Models, Animal Laparoscopy* Male Rats Rats, Wistar Receptors, Neurokinin-1 / antagonists & inhibitors* Recurrence Tissue Adhesions / prevention & control*, surgery* |
| Chemical | |
Reg. No./Substance:
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0/6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid; 0/Bicyclo Compounds, Heterocyclic; 0/Receptors, Neurokinin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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