Document Detail

The neuroimaging signal is a linear sum of neurally distinct stimulus- and task-related components.
MedLine Citation:
PMID:  22842146     Owner:  NLM     Status:  MEDLINE    
Neuroimaging (for example, functional magnetic resonance imaging) signals are taken as a uniform proxy for local neural activity. By simultaneously recording electrode and neuroimaging (intrinsic optical imaging) signals in alert, task-engaged macaque visual cortex, we recently observed a large anticipatory trial-related neuroimaging signal that was poorly related to local spiking or field potentials. We used these same techniques to study the interactions of this trial-related signal with stimulus-evoked responses over the full range of stimulus intensities, including total darkness. We found that the two signals could be separated, and added linearly over this full range. The stimulus-evoked component was related linearly to local spiking and, consequently, could be used to obtain precise and reliable estimates of local neural activity. The trial-related signal likely has a distinct neural mechanism, however, and failure to account for it properly could lead to substantial errors when estimating local neural spiking from the neuroimaging signal.
Mariana M B Cardoso; Yevgeniy B Sirotin; Bruss Lima; Elena Glushenkova; Aniruddha Das
Related Documents :
9744096 - Combinatorial interaction of light-responsive elements plays a critical role in determi...
12682226 - Light (a cellular ligand for herpes virus entry mediator and lymphotoxin receptor)-medi...
16661386 - Density of microbodies on sucrose gradients during phytochrome-mediated glyoxysome pero...
16659366 - Control by phytochrome of cytoplasmic and plastid rrna accumulation in cotyledons of mu...
25135356 - Loudness modulation after transient and permanent hearing loss: implications for tinnit...
18263176 - Investigation of new low-loss and high-power saw filters for reverse-frequency-allocate...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-29
Journal Detail:
Title:  Nature neuroscience     Volume:  15     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-30     Completed Date:  2012-11-05     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1298-306     Citation Subset:  IM    
Department of Neuroscience, Columbia University, New York, New York, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cerebrovascular Circulation / physiology
Conditioning, Operant
Electrodes, Implanted
Electrophysiological Phenomena
Evoked Potentials / physiology
Fixation, Ocular / physiology
Image Processing, Computer-Assisted
Linear Models
Macaca mulatta
Nervous System Physiological Processes*
Neuroimaging / methods*
Photic Stimulation
Visual Cortex / physiology
Grant Support
P30 EY019007/EY/NEI NIH HHS; R01 EY019500/EY/NEI NIH HHS; R01 EY019500/EY/NEI NIH HHS; R01 NS063226/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1.
Next Document:  Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ.