Document Detail


The neuroimaging signal is a linear sum of neurally distinct stimulus- and task-related components.
MedLine Citation:
PMID:  22842146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuroimaging (for example, functional magnetic resonance imaging) signals are taken as a uniform proxy for local neural activity. By simultaneously recording electrode and neuroimaging (intrinsic optical imaging) signals in alert, task-engaged macaque visual cortex, we recently observed a large anticipatory trial-related neuroimaging signal that was poorly related to local spiking or field potentials. We used these same techniques to study the interactions of this trial-related signal with stimulus-evoked responses over the full range of stimulus intensities, including total darkness. We found that the two signals could be separated, and added linearly over this full range. The stimulus-evoked component was related linearly to local spiking and, consequently, could be used to obtain precise and reliable estimates of local neural activity. The trial-related signal likely has a distinct neural mechanism, however, and failure to account for it properly could lead to substantial errors when estimating local neural spiking from the neuroimaging signal.
Authors:
Mariana M B Cardoso; Yevgeniy B Sirotin; Bruss Lima; Elena Glushenkova; Aniruddha Das
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-29
Journal Detail:
Title:  Nature neuroscience     Volume:  15     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-30     Completed Date:  2012-11-05     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1298-306     Citation Subset:  IM    
Affiliation:
Department of Neuroscience, Columbia University, New York, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Cerebrovascular Circulation / physiology
Conditioning, Operant
Cues
Darkness
Electrodes, Implanted
Electrophysiological Phenomena
Evoked Potentials / physiology
Fixation, Ocular / physiology
Hemodynamics
Image Processing, Computer-Assisted
Linear Models
Macaca mulatta
Nervous System Physiological Processes*
Neuroimaging / methods*
Neurophysiology*
Photic Stimulation
Visual Cortex / physiology
Grant Support
ID/Acronym/Agency:
P30 EY019007/EY/NEI NIH HHS; R01 EY019500/EY/NEI NIH HHS; R01 EY019500/EY/NEI NIH HHS; R01 NS063226/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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