Document Detail

The neurofilament heavy chain (NfH) in the cerebrospinal fluid diagnosis of Alzheimer's disease.
MedLine Citation:
PMID:  16484807     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Attempting to improve the cerebrospinal fluid (CSF) diagnosis of Alzheimer's disease (AD), the neurofilament heavy chain isoform, NfH(SMI35) was compared to other CSF markers [total tau, phospho-tau, amyloid beta 1-42 (Abeta42), the ratio of amyloid beta fragments Abeta42/Abeta40 (Abeta ratio)]. METHODS: CSF levels were determined in patients with AD (n = 109), mild cognitive impairment (MCI, n = 25), frontotemporal dementia (n = 15), vascular dementia (VD, n = 41), and controls (n = 58). RESULTS: CSF NfH(SMI35) was elevated in AD and VD as compared to controls (p < 0.05). Total tau was higher in AD as compared to controls (p < 0.05). CSF phospho-tau was elevated in AD as compared to controls and VD (p < 0.05 each). CSF Abeta42 and Abeta ratios in AD were lower than in MCI and controls (p < 0.05 each). CONCLUSION: The diagnostic potential of NfH(SMI35) is not superior to that of other CSF markers.
Johannes Brettschneider; Axel Petzold; Daniel Schottle; Annett Claus; Matthias Riepe; Hayrettin Tumani
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-02-10
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  21     ISSN:  1420-8008     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-10     Completed Date:  2006-10-17     Revised Date:  2008-03-24    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  291-5     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2006 S. Karger AG, Basel.
Department of Neurology, University of Ulm, Ulm, Germany.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / cerebrospinal fluid*,  diagnosis*
Amyloid beta-Protein / cerebrospinal fluid
Dementia / cerebrospinal fluid,  diagnosis,  pathology
Dementia, Vascular / cerebrospinal fluid,  diagnosis
Diagnosis, Differential
Frontal Lobe / pathology
Middle Aged
Neurofilament Proteins / cerebrospinal fluid*
Peptide Fragments / cerebrospinal fluid
Temporal Lobe / pathology
tau Proteins / cerebrospinal fluid
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Neurofilament Proteins; 0/Peptide Fragments; 0/amyloid beta-protein (1-42); 0/tau Proteins

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