| [The neuroendocrine axis and the pathophysiology of sepsis]. | |
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MedLine Citation:
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PMID: 20839147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immune system and the central nervous system are able to affect each other. Proinflammatory cytokines induce the expression of CRH or AVP in the hypothalamus and ACTH in the pituitary gland. Thus, enhanced adrenal release of cortisol suppresses the activation of NF-κB and activates antiinflammatory cytokines. The cholinergic antiinflammatory pathway, the efferent arm of the inflammatory reflex, is another mechanism of the CNS to control inflammation. It consists of the efferent vagus nerve, the neurotransmitter actylcholine and the α7 subunit of the nicotinic acteylcholine receptor. Probably, the transmission of information takes place to postsynaptic sympathetic fibres in the celiac plexus which terminate in the spleen and act on splenic immune cells. Cholinesterase inhibitors have antiinflammatory effects in experimental sepsis when administered early. |
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Authors:
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Katja Weismüller; Michael Bauer; Stefan Hofer; Markus A Weigand |
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Publication Detail:
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Type: English Abstract; Journal Article Date: 2010-09-13 |
Journal Detail:
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Title: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Volume: 45 ISSN: 1439-1074 ISO Abbreviation: Anasthesiol Intensivmed Notfallmed Schmerzther Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-14 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9109478 Medline TA: Anasthesiol Intensivmed Notfallmed Schmerzther Country: Germany |
Other Details:
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Languages: ger Pagination: 574-8; quiz 579 Citation Subset: IM |
Copyright Information:
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© Georg Thieme Verlag Stuttgart · New York. |
Affiliation:
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Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie des Universitätsklinikums Giessen und Marburg GmbH, Standort Giessen. Katja.Weismueller@chiru.med.uni-giessen.de |
Vernacular Title:
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Sepsis - Die Bedeutung der neuroendokrinen Achse in der Pathophysiologie der Sepsis. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokines / immunology* Humans Models, Immunological* Neurosecretory Systems / immunology* Sepsis / immunology* Signal Transduction / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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