| The neurochemistry of phenylketonuria. | |
| | |
MedLine Citation:
|
PMID: 11043156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CONCLUSION: The severe brain disease found in phenylketonuria is caused by a raised blood phenylalanine content which increases the brain free phenylalanine and decreases the concentration of other large neutral amino acids. Brain protein synthesis is decreased, myelin turnover is increased and there are abnormalities in amine neurotransmitter systems. |
| | |
Authors:
|
R Surtees; N Blau |
Related Documents
:
|
9571706 - Amino acid metabolism, branched-chain amino acid feeding and brain monoamine function. 1133786 - The requirements of the brain for some amino acids. 3831696 - Natural-abundance 13c nmr of brain. 21153096 - Dual pathways for carbamylcholine-stimulated arachidonic acid release in rat pancreatic... 16434056 - Cerebrospinal fluid kynurenic acid in male and female controls - correlation with monoa... 16682516 - Fatty acid synthase and its mrna concentrations are decreased at different times follow... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: European journal of pediatrics Volume: 159 Suppl 2 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2000 Oct |
Date Detail:
|
Created Date: 2001-02-08 Completed Date: 2001-02-08 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: GERMANY |
Other Details:
|
Languages: eng Pagination: S109-13 Citation Subset: IM |
Affiliation:
|
Institute of Child Health (UCLMS), London, UK. r.surtees@ich.ucl.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids
/
metabolism Animals Brain / metabolism Brain Chemistry / physiology* Dopamine / metabolism Humans Myelin Sheath / metabolism Nerve Tissue Proteins / biosynthesis Phenylketonurias / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 0/Nerve Tissue Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The neuropathology of phenylketonuria: human and animal studies.
Next Document: Adult care in phenylketonuria and hyperphenylalaninaemia: the relevance of neurological abnormalitie...