Document Detail

The neurochemistry of phenylketonuria.
MedLine Citation:
PMID:  11043156     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: The severe brain disease found in phenylketonuria is caused by a raised blood phenylalanine content which increases the brain free phenylalanine and decreases the concentration of other large neutral amino acids. Brain protein synthesis is decreased, myelin turnover is increased and there are abnormalities in amine neurotransmitter systems.
R Surtees; N Blau
Related Documents :
9571706 - Amino acid metabolism, branched-chain amino acid feeding and brain monoamine function.
1133786 - The requirements of the brain for some amino acids.
3831696 - Natural-abundance 13c nmr of brain.
21153096 - Dual pathways for carbamylcholine-stimulated arachidonic acid release in rat pancreatic...
16434056 - Cerebrospinal fluid kynurenic acid in male and female controls - correlation with monoa...
16682516 - Fatty acid synthase and its mrna concentrations are decreased at different times follow...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of pediatrics     Volume:  159 Suppl 2     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-02-08     Completed Date:  2001-02-08     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  S109-13     Citation Subset:  IM    
Institute of Child Health (UCLMS), London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acids / metabolism
Brain / metabolism
Brain Chemistry / physiology*
Dopamine / metabolism
Myelin Sheath / metabolism
Nerve Tissue Proteins / biosynthesis
Phenylketonurias / metabolism*
Reg. No./Substance:
0/Amino Acids; 0/Nerve Tissue Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The neuropathology of phenylketonuria: human and animal studies.
Next Document:  Adult care in phenylketonuria and hyperphenylalaninaemia: the relevance of neurological abnormalitie...