Document Detail

The neurochemistry of phenylketonuria.
MedLine Citation:
PMID:  11043156     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: The severe brain disease found in phenylketonuria is caused by a raised blood phenylalanine content which increases the brain free phenylalanine and decreases the concentration of other large neutral amino acids. Brain protein synthesis is decreased, myelin turnover is increased and there are abnormalities in amine neurotransmitter systems.
R Surtees; N Blau
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of pediatrics     Volume:  159 Suppl 2     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-02-08     Completed Date:  2001-02-08     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  S109-13     Citation Subset:  IM    
Institute of Child Health (UCLMS), London, UK.
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MeSH Terms
Amino Acids / metabolism
Brain / metabolism
Brain Chemistry / physiology*
Dopamine / metabolism
Myelin Sheath / metabolism
Nerve Tissue Proteins / biosynthesis
Phenylketonurias / metabolism*
Reg. No./Substance:
0/Amino Acids; 0/Nerve Tissue Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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